Quick Answer
Large table indexing considerations: index creation is slow (reads all rows) and blocks writes by default (MySQL 5.6+ has Online DDL for InnoDB). Indexes consume disk space and slow down writes. Use ONLINE algorithm for adding indexes: ALTER TABLE ... ADD INDEX ... ALGORITHM=INPLACE, LOCK=NONE. Analyze query patterns before adding indexes. More isn't better - each index has a write cost.
Answer
Indexing large tables may involve rebuilding indexes and using memory buffers. Online DDL and partitioning help avoid downtime.
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Verified Answer
This answer has been peer-reviewed by industry experts holding senior engineering roles to ensure technical accuracy and relevance for modern interview standards.